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What You Need to Know About Genetics and Prostate Cancer

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What is a ‘cancer gene’? How genetic mutations lead to cancer IPCSG Newsletter A Patient-Friendly Guide for the Informed Prostate Cancer Support Group February 2026  |  Informed Prostate Cancer Support Group (IPCSG) BLUF — Bottom Line Up Front • About 12% of all prostate cancers are driven by inherited (germline) gene mutations, most commonly in BRCA2, BRCA1, ATM, CHEK2, and the Lynch syndrome genes. • Men carrying a BRCA2 mutation face a 2–8× higher lifetime risk of prostate cancer, more aggressive disease, and earlier onset than the general population. • NCCN guidelines now recommend genetic counseling and testing for all men with metastatic, high-risk, or very-high-risk prostate cancer, as well as those with a suggestive family history. • Your germline mutation status can directly guide treatment: PARP inhibitors (olaparib, rucaparib, niraparib, talazoparib) are FDA-approved specifically for men whose tumors harbor HRR-pathway mutations. • Tumor (somatic) genetic testing an...
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The PSE Prostate Cancer Test is 270% Better Than PSA - YouTube

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This Prostate Cancer Test is 270% Better Than PSA - YouTube I now have solid information to write a well-sourced article. Let me compose the IPCSG newsletter piece. IPCSG Newsletter A New Blood Test That Could Revolutionize Prostate Cancer Screening: What You Need to Know About EpiSwitch PSE BLUF (Bottom Line Up Front): A real test called EpiSwitch PSE — developed by UK researchers and now available in the United States — combines a standard PSA reading with five epigenetic biomarkers to detect prostate cancer with 94% accuracy, compared to roughly 55% for PSA alone. The test is not FDA-cleared but is available as a lab-developed test through a CLIA-certified laboratory in Maryland, and is already reimbursed by Medicare, Humana, UnitedHealthcare, and Optum Health. A 2025 real-world study showed it can reduce unnecessary biopsies by up to 79%. For men on active surveillance or navigating elevated PSA results, this test may offer a meaningful additional tool — though it does not re...
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