Morphologic patterns observed in prostate biopsy cases with discrepant grade group and molecular risk classification - Greenland - The Prostate - Wiley Online Library
Morphologic patterns observed in prostate biopsy cases with discrepant grade group and molecular risk classification - Greenland - The Prostate - Wiley Online Library onlinelibrary.wiley.com Nancy Y. Greenland MD, PhD Summary This study investigated the morphologic patterns observed in prostate biopsy cases where the Grade Group (GG) and molecular risk classification using the Decipher test were discrepant. Key findings: - Out of 178 cases, 41 (23%) had discrepant Decipher risk and GG. 33 of these had slides available for review. - Of the 33 discrepant cases, 70% were GG1-2 with high Decipher risk and 30% were GG3-5 with low Decipher risk. - For the GG1 cases with high Decipher risk, unusual and difficult to grade histologic patterns were frequent, including atrophic carcinoma, collagenous fibroplasia, and mucin rupture. However, these patterns are thought to be lower risk based on prior studies. - For the