Informed Prostate Cancer Patient Support

  What PCWG4 Means for You Informed Prostate Cancer Support Group (IPCSG) Member Newsletter San Diego, California May 2026 Issue Clinical Trials & Research Update   Prepared for IPCSG Members by the Newsletter Staff • Published May 2026 Bottom Line Up Front (BLUF) An international panel of more than 40 prostate cancer specialists has issued a landmark update — the Prostate Cancer Working Group 4 ( PCWG4 ) report — that rewrites the standards used to design and conduct clinical trials for advanced prostate cancer. Published in February 2026 in the Journal of Clinical Oncology , PCWG4 replaces stigmatizing "castration" language with biology-based terminology, formally integrates the powerful PSMA-PET scan into trial rules, refines how progression is measured so patients are not pulled from beneficial treatments prematurely, and demands that patient quality-of-life ...

 Interactive Figure Your DNA May Already Know How Aggressive Your Prostate Cancer Will Be Informed Prostate Cancer Support Group  |  Patient Education Series A landmark VA-led study introduces a new genetic score that predicts cancer aggressiveness — and could soon change how active surveillance is managed. Prepared for the IPCSG Newsletter  |  May 2026  |  Source study: medRxiv preprint, doi: 10.64898/2026.05.07.26352488  |  Note: preprint, not yet peer-reviewed. Bottom Line Up Front (BLUF) A new genetic score called PRSagg , developed from DNA data on nearly 40,000 veterans, can predict how aggressive a man's prostate cancer is likely to be — independent of PSA, age, or biopsy grade. In the largest validation study of its kind, men with the highest PRSagg had more than twice the risk of their cancer spreading (metastasis) compared to men with the lowest score. Crucially, this...