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Teaching Cancer Cells to Remember Who They Used to Be:

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This image shows patient derived tumor organoids before (top) and after treatment (bottom).  The colors show the activation of pathways related to cell differentiation in cancer stem cells.  Shortly after these images were taken, the cancer stem cells spontaneously collapsed.  Photo credit: Pradipta Ghosh/HUMANOID What the New Science of Cancer Reversion Means for Prostate Cancer Patients Breakthrough studies from Korea and San Diego have demonstrated that cancer cells can be reprogrammed back toward normality — not killed, but re-educated. The implications for prostate cancer patients — from newly diagnosed to late-stage mCRPC — are potentially profound.   Special Science Update — March 2026 Prepared by the IPCSG Educational Committee   Bottom Line Up Front  A cluster of recent studies — led by researchers at KAIST in South Korea and UC San Diego — has demonstrated that cancer cells can be systemati...
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Plastics Inside the Prostate:

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Microplastics found in 90% of prostate cancer tumors, study reveals | ScienceDaily What the Latest Research Tells Us About Microplastics and Prostate Cancer A growing body of evidence links tiny plastic particles found inside human tumors to potential cancer risk — but scientists urge caution about overstating a still-early finding. February 28, 2026 Bottom Line Up Front (BLUF) Two independent research teams — one at NYU Langone Health (February 2026) and one at Peking University (September 2024) — have detected microplastics inside prostate tumors at concentrations roughly 1.5 to 2.5 times higher than in adjacent noncancerous prostate tissue. Laboratory research from the Peking University group also shows that polystyrene microplastics can directly stimulate human prostate cancer cells to multiply. These are striking findings, but both research teams urge the same caution: the studies are small, no one has yet proven that microplastics cause prostate ...
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Iron Metabolism as a Therapeutic Vulnerability in Stem Cell-Like Castration-Resistant Prostate Cancer | bioRxiv

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Iron Metabolism as a Therapeutic Vulnerability in Stem Cell-Like Castration-Resistant Prostate Cancer | bioRxiv Iron: The Hidden Fuel Driving a Stubborn Subtype of Castration-Resistant Prostate Cancer — And a New Way to Turn It Against the Tumor Researchers discover that "stem cell-like" CRPC cells depend on iron to survive — and that disrupting iron balance triggers a lethal form of cell death in those cells while leaving others largely untouched. BLUF — Bottom Line Up Front A new laboratory study published in February 2026 from the University of Bern (Switzerland) and McGill University (Canada) has identified a potentially exploitable weakness in one of the most treatment-resistant subtypes of castration-resistant prostate cancer (CRPC). The "stem cell-like" subtype (CRPC-SCL), which accounts for roughly 25% of CRPC cases and resists standard hormone therapy, is uniquely dependent on iron. Cells in this subtype accumulate excess iron...
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