'Most Compelling' Data Yet for Metastasis-Directed Therapy in Prostate Cancer | MedPage Today
'Most Compelling' Data Yet for Metastasis-Directed Therapy in Prostate Cancer | MedPage Today Metastasis-Directed Therapy Shows Promise for Oligometastatic Prostate Cancer BLUF (Bottom Line Up Front): A major new meta-analysis of six randomized trials provides the strongest evidence yet that metastasis-directed therapy (MDT)—using targeted radiation or surgery to treat a limited number of cancer metastases—significantly delays disease progression in men with oligometastatic prostate cancer. While the treatment improved multiple important survival measures, the improvement in overall survival narrowly missed statistical significance. This approach represents a potential paradigm shift for patients with limited metastatic spread, though experts note that modern PSMA-PET imaging may further improve patient selection for this strategy. Understanding Oligometastatic Disease Oligometastatic prostate cancer represents an intermediate state between localized disease and widespread ...