Informed Prostate Cancer Patient Support

Utility of Ga68 prostate‐specific membrane antigen positron‐emission tomography for pre‐operative staging of high‐risk prostate cancer in a prospective cohort - Tarr - - Journal of Medical Imaging and Radiation Oncology - Wiley Online Library : Introduction To assess the yield of Ga68 PSMA PET/CT added to the conventional staging of high‐risk prostate cancer in terms of altered staging and changes to management. Methods Patients with hig...

On the Cusp: Straddling the Emotional & Physical Reality of a Prostate Cancer Diagnosis | UCSF Radiology : A year ago, long-time San Franciscan and hospitality entrepreneur Chip Conley received a shocking diagnosis - he had intermediate-stage prostate cancer.

Prostate Cancer Genomic Classifier Appears Effective for Improved Patient Outcomes | Cancer Network : When treatment decisions were made using a prostate genomic classifier after radical prostatectomy in men with prostate cancer, patient outcomes significantly improved.

Ultrasound with MRI improves prostate treatment : Combining ultrasound heat with precision MRI promises a more precise way to treat prostate cancer and enlarged prostates — without the usual side effects. medicalnewstoday.com Ultrasound with MRI improves prostate treatment 5-6 minutes MRI-guided transurethral ultrasound ablation (TULSA) is a new tool for the highly accurate treatment of prostate cancer — without the usual side effects. Ultrasound scans guided by real time MRI may improve prostate cancer treatment. Prostate cancer is the second leading cause of cancer death among males. Although the 5 year survival rate with early detection and nonaggressive forms is 99% , 1 in 9 males will receive a diagnosis of prostate cancer at some point in their lives. Currently, there are two common treatment options: surgical removal of the prostate and radiation therapy . Although these are usually effective, they come with side effects,

Should all prostate needle biopsy Gleason score 4 + 4 = 8 prostate cancers be high risk? Implications for shared decision-making and patient counselling. : To estimate the probability of downgrading to Gleason score ≤7 at radical prostatectomy for men with a prostate needle biopsy demonstrating Gleason score 8 (4 + 4).This is a retrospective review of men with Gleason score 8 (4 + 4) prostate cancer on needle biopsy who then underwent a radical prostatectomy at the Karmanos Cancer Institute or the University of Michigan. urotoday.com Should all prostate needle biopsy Gleason score 4 + 4 = 8 prostate cancers be high risk? Implications for shared decision-making and patient counselling. 3 minutes To estimate the probability of downgrading to Gleason score ≤7 at radical prostatectomy for men with a prostate needle biopsy demonstrating Gleason score 8 (4 + 4). This is a retrospective review of men with Gleason score 8 (4 + 4) prosta

Diagnostic accuracy of prostate cancer antigen 3 (PCA3) prior to first prostate biopsy: A systematic review and meta-analysis. : We aimed to determine the diagnostic accuracy of the prostate cancer antigen 3 (PCA3) test before performing the first biopsy compared with prostate biopsy for the diagnosis of prostate cancer.A systematic search was performed in MEDLINE, EMBASE, CENTRAL, LILACS, reference lists, specialized journals in urology and cancer, and unpublished literature. urotoday.com Diagnostic accuracy of prostate cancer antigen 3 (PCA3) prior to first prostate biopsy: A systematic review and meta-analysis. 2 minutes December 26, 2019 We aimed to determine the diagnostic accuracy of the prostate cancer antigen 3 (PCA3) test before performing the first biopsy compared with prostate biopsy for the diagnosis of prostate cancer. A systematic search was performed in MEDLINE, EMBASE, CENTRAL, LILACS, reference lists,

Outcomes of treatment for localized prostate cancer in a single institution: comparison of radical prostatectomy and radiation therapy by propensity score matching analysis | SpringerLink : To compare the outcomes of radical prostatectomy (RP), intensity-modulated radiation therapy (IMRT), and low-dose-rate brachytherapy (BT) using propensity Conclusion The results of our propensity score analysis of mid-term localized prostate cancer treatment outcomes demonstrated no significant differences in the overall survival rate. Despite the difference in biochemical failure definition between surgery and radiotherapeutic approaches, the results of this study demonstrate improved biochemical control favoring IMRT and BT as compared to RP. This is a preview of subscription content, log in to check access. link.springer.com Outcomes of treatment for locali

Determinants for choosing and adhering to active surveillance for localised prostate cancer: a nationwide population-based study | BMJ Open : Determinants for choosing and adhering to active surveillance for localised prostate cancer: a nationwide population-based study 22-28 minutes Determinants for choosing and adhering to active surveillance for localised prostate cancer: a nationwide population-based study Oskar Bergengren 1 , Hans Garmo 2 , Ola Bratt 3 , Lars Holmberg 1 , Eva Johansson 1 , Anna Bill-Axelson 1 Abstract Objective Knowledge about factors influencing choice of and adherence to active surveillance (AS) for prostate cancer (PC) is scarce. We aim to identify which factors most affected choosing and adhering to AS and

Targeted screening could prevent one in six prostate cancer deaths -- ScienceDaily : The study modeled the harms and benefits of introducing four-yearly PSA screening for all men aged 55 to 69 versus more targeted checks for those at higher risk of the disease. The researchers concluded that the best approach would be to screen men at a slightly higher genetic risk - nearly half of men in that age group -- as this would have the biggest health benefit, preventing deaths from prostate cancer while minimizing unnecessary treatments for harmless tumors. sciencedaily.com Targeted screening could prevent one in six prostate cancer deaths 5-6 minutes Nearly one in six deaths from prostate cancer could be prevented if targeted screening was introduced for men at a higher genetic risk of the disease, according to a new UCL-led computer modelling study. Prostate cancer is the most common form of cancer in men with around 130 n

The Hidden Role of Radiologists in Prostate Cancer Treatment, Research, and Support | UCSF Radiology : With over 15 of experience in radiology, and as an internationally-recognized expert in the use of imaging for the detection and treatment of genitourinary diseases such as prostate cancer, Antonio Westphalen, MD considers the role radiologists play in overall patient care significant. radiology.ucsf.edu The Hidden Role of Radiologists in Prostate Cancer Treatment, Research, and Support 3-4 minutes With over 15 of experience in radiology, and as an internationally-recognized expert in the use of imaging for the detection and treatment of genitourinary diseases such as prostate cancer, Antonio Westphalen, MD considers the role radiologists play in overall patient care significant. "It's important for patients to realize that there is a group of people involved in their care, and in that group is

Chemo Triumphs in Second-Line Metastatic Prostate Cancer : 'Practice-changing' results show that cabazitaxel is superior to androgen-signaling inhibitors in second-line treatment of metastatic castrate-resistant prostate cancer. medscape.com Chemo Triumphs in Second-Line Metastatic Prostate Cancer Pam Harrison 4-5 minutes Chemotherapy with cabazitaxel ( Jevtana, Sanofi-Aventis) beat treatment with an androgen-signaling inhibitor in the second-line treatment of metastatic castrate-resistant prostate cancer (mCRPC). The first-line treatment for these patients was with docetaxel and then with one of the androgen-signaling inhibitors, either abiraterone (multiple brands) or enzalutamide (Xtandi, Astellas). However, there was evidence of rapid disease progression, and so second-line treatment with either cabazitaxel or the other androgen-signaling inhibitor was initiated. The results showed that m

Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD | NEJM : Editorial from The New England Journal of Medicine — Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD nejm.org Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD Emmanuel S. Antonarakis 3-4 minutes This

Image-guided dose-escalated radiation therapy for localized prostate cancer with helical tomotherapy | SpringerLink : Purpose To evaluate treatment outcomes for patients with localized prostate cancer who were treated with dose-escalated primary image-guided radiation therapy (IGRT). link.springer.com Image-guided dose-escalated radiation therapy for localized prostate cancer with helical tomotherapy AuthorsAuthors and affiliations 12-15 minutes Tomasz Barelkowski Peter Wust David Kaul Sebastian Zschaeck Waldemar Wlodarczyk Volker Budach Pirus Ghadjar Marcus Beck   Abstract Purpose To evaluate treatment outcomes for patients with localized prostate cancer who were treated with dose-escalated primary image-guided radiation therapy (IGRT). Methods We retrospectively analyzed 88 consecutive patients treated using helical tomotherapy with daily megavoltage CTs (MVCT). Patients were p

JCI - Genomics of lethal prostate cancer at diagnosis and castration-resistance jci.org Genomics of lethal prostate cancer at diagnosis and castration-resistance Joaquin Mateo, 7-8 minutes Research In-Press Preview Cell biology Oncology Free access | 10.1172/JCI132031 George Seed, Claudia Bertan, Pasquale Rescigno, David Dolling, Ines Figueiredo, Susana Miranda, Daniel Nava Rodrigues, Bora Gurel, Matthew Clarke, Mark Atkin, Rob Chandler, Carlo Messina, Semini Sumanasuriya, Diletta Bianchini, Maialen Barrero, Antonella Petremolo, Zafeiris Zafeiriou, Mariane Sousa Fontes, Raquel Perez-Lopez, Nina Tunariu, Ben A. Fulton, Robert Jones, Ursula B. McGovern, Christy Ralph, Mohini Varughese, Omi Parikh, Suneil Jain, Tony Elli

miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA - ScienceDirect : sciencedirect.com miR-191 promotes radiation resistance of prostate cancer through interaction with RXRA 46-58 minutes Under a Creative Commons license open access Highlights • miR-191 expression is elevated in prostate cancer patients with higher Gleason score. •High miR-191 promotes radiation survival and targets retinoid X receptor alpha, RXRA. •Treatment with the RXRA agonist 9-cis-retinoic acid restores radiosensitivity. •Patients with high miR-191 and low RXRA experienced quicker biochemical recurrence. Abstract Radiation therapy is a common treatment for prostate cancer, however recurrence remains a problem. MicroRNA expression is altered in prostate cancer and may promote therapy resistance. Through bioinformatic analyses of TCGA and CPC-GENE patient cohorts, we identified higher miR-191 expression in