Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD | NEJM

Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD | NEJM: Editorial from The New England Journal of Medicine — Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD



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Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD

Emmanuel S. Antonarakis
3-4 minutes

















































































































































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List of authors.
  • Mario A. Eisenberger, M.D.,
  • and Emmanuel S. Antonarakis, M.D.



































This article has no abstract; the first 100 words appear below.

Since
2004, eight therapeutic agents have received approval from the Food and
Drug Administration for the treatment of men with advanced prostate
cancer. Four are androgen-signaling–targeted inhibitors that impair
androgen-receptor function (abiraterone, enzalutamide, apalutamide, and
darolutamide), two are taxane chemotherapies that suppress microtubule
dynamics (docetaxel and cabazitaxel), one is a bone-targeted α-emitting
radiopharmaceutical agent (radium-223), and one is an autologous
cell–based immunotherapy (sipuleucel-T).1 The pivotal trials
for these agents generally compared the new therapy with placebo or a
non–life-prolonging treatment and were designed primarily to satisfy
regulatory requirements for drug approval, thus preventing insights
about comparative efficacy or appropriate treatment . .

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