Informed Prostate Cancer Patient Support

Morphologic patterns observed in prostate biopsy cases with discrepant grade group and molecular risk classification - Greenland - The Prostate - Wiley Online Library onlinelibrary.wiley.com Nancy Y. Greenland MD, PhD Summary This study investigated the morphologic patterns observed in prostate biopsy cases where the Grade Group (GG) and molecular risk classification using the Decipher test were discrepant. Key findings: - Out of 178 cases, 41 (23%) had discrepant Decipher risk and GG. 33 of these had slides available for review. - Of the 33 discrepant cases, 70% were GG1-2 with high Decipher risk and 30% were GG3-5 with low Decipher risk. - For the GG1 cases with high Decipher risk, unusual and difficult to grade histologic patterns were frequent, including atrophic carcinoma, collagenous fibroplasia, and mucin rupture. However, these patterns are thought to be lower risk based on prior studies. - For the

Firefighters may have higher prostate cancer risk - Futurity futurity.org Shipherd Reed-Arizona Summary The study examined whether firefighting experience and exposure to per- and polyfluoroalkyl substances (PFAS) are associated with DNA methylation changes in regions previously linked to prostate cancer risk among male U.S. firefighters. Key findings: Incumbent firefighters had different DNA methylation patterns compared to academy firefighters at 15 CpG sites and 1 differentially methylated region within chromosome 8q24, a region linked to prostate cancer. Years of firefighting experience was associated with increased methylation of the Alu repetitive element, also previously linked to prostate cancer risk. Detection of branched PFOA (SbPFOA) was associated with differential methylation at 19 CpG sites in 8q24. However, this likely reflected an environmental rather than occupational exposure. Overal