Revolutionary Approach: Skipping Biopsy after PSMA PET/CT for Prostate Cancer Surgery Shows Promise
Radical prostatectomy without prior biopsy: an initial decision-making algorithm based on PSMA PET/mpMRI | Prostate Cancer and Prostatic Diseases BLUF (Bottom Line Up Front) Chinese researchers have successfully performed prostate cancer surgery on 120 men without prior biopsy, using advanced imaging alone to diagnose cancer. Published January 31, 2026, in Prostate Cancer and Prostatic Diseases , this study achieved 100% accuracy in detecting clinically significant cancer using a careful algorithm combining PSMA PET/CT and multiparametric MRI scans. While this radical departure from standard practice shows promise for carefully selected patients, it remains experimental and requires independent validation before becoming routine care. The Traditional Path—And Its Problems For decades, prostate biopsy has been the gold standard for diagnosing prostate cancer. A urologist inserts a needle through the rectal wall 10-12 times to collect tissue samples, guided by ultrasound. The procedu...