Informed Prostate Cancer Patient Support

How gut microbes meddle with cancer immunotherapy | Drug Discovery News drugdiscoverynews.com Despite being classified as distinct entities, the nervous and immune systems work interdependently. In the brain, skin, and gastrointestinal tract, the interplay between the nervous and immune systems, known as the neuro-immune axis, orchestrates a variety of physiological processes.  “It fascinated me how cells in these two systems talk to each other,” said Isaac Chiu , an immunobiologist at Harvard Medical School who spent graduate school investigating the crosstalk between T cells and microglia in neurodegeneration.  Immunobiologist Isaac Chiu at Harvard Medical School aims to define the role of bacteria in neuroimmune interactions in health and disease. CREDIT: ISSAC CHIU Further research led him to an even more complex situation. During his postdoctoral research on bacterial skin infections, Chiu disc...

Whole exome germline sequencing in early‐onset prostate cancer patients: Genomic findings and clinical outcomes - Siegelmann‐Danieli - The Prostate - Wiley Online Library onlinelibrary.wiley.com Nava Siegelmann-Danieli MD 1 INTRODUCTION Prostate cancer is the second most common solid tumor diagnosed in men worldwide. In 2020, there were over 1.4 million estimated new prostate cancer cases worldwide. 1 In the United States, the majority of prostate cancer patients (62%) are diagnosed at 65 years or older, and the median age at diagnosis is 67 years. 2 In recent years, significant advances in somatic testing using whole genome and whole exome sequencing (WES) of tumor samples derived from primary, advanced, and metastatic disease led to in-depth genome-based characterization of prostate tumors...

Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate - Ertunc - The Prostate - Wiley Online Library onlinelibrary.wiley.com Onur Ertunc MD Abstract Background Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been developed for this purpose. However, fluorescent-based tissue assays are cumbersome for investigators to undertake, both in research and clinical settings. Methods A robust chromogenic in situ hybridization (CISH) approach was developed to visualize and quantify telomere content at single cell resolution in human prostate tissues, ...