Patients helping researchers to advance treatments for prostate cancer -- ScienceDaily

Patients helping researchers to advance treatments for prostate cancer -- ScienceDaily

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Navigating therapeutic sequencing in the metastatic castration-resistant prostate cancer patient journey | Prostate Cancer and Prostatic Diseases

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Actinium-225 Theranostics for Advanced Prostate Cancer:

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 A Patient's Guide to the State of the Science An IPCSG patient-education feature — April 2026 BLUF (Bottom Line Up Front):   Actinium-225 (Ac-225) PSMA-targeted alpha therapy is producing some of the most striking PSA response numbers ever seen in heavily pretreated mCRPC — about 65% of men achieve a PSA50 response across pooled studies, a figure that exceeds what beta-emitting Lu-177 PSMA delivers in the same setting. It is showing meaningful activity even in men who have already progressed through Pluvicto (Lu-177 PSMA-617). However, Ac-225 PSMA therapy is not a finished product: it remains investigational only — no Ac-225 drug has FDA approval for prostate cancer as of April 2026 — and the dominant problem is severe, often permanent, dry mouth (xerostomia) from off-target damage to the salivary glands, which is reported in roughly 80–85% of treated patients. A wave of randomized phase 2/3 trials (PSMAcTION, CONVERGE-01, AcTION, TATCIST, ACCEL, AlphaBreak...
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