Dose-escalated Radiotherapy Plus Long-term Androgen Deprivation Therapy Is Safe And Effective For Patients With High-risk Prostate Cancer | Dr. Catalona

Dose-escalated Radiotherapy Plus Long-term Androgen Deprivation Therapy Is Safe And Effective For Patients With High-risk Prostate Cancer | Dr. Catalona

drcatalona.com
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© Wade Douglas Carden, MD

A study, recently presented at the American Society of Clinical Oncology Genitourinary Cancers Symposium in San Francisco found that high-risk prostate cancer patients benefit from dose-escalation radiotherapy in combination with long-term androgen deprivation therapy (ADT) with no increase in long-term toxicity.

The phase-3 trial of patients with high-risk prostate cancer and negative lymph node status was randomly assigned to receive either dose-escalated or conventional dose radiotherapy with ADT given to both groups.

The researchers found significantly improved biochemical or clinical progression-free survival in the dose- escalated group versus the conventional-dose group. Also, theresearchers found significant differences in prostate cancer-specific survival and overall survival. Late toxicities did not significantly differ between dose-escalated and conventional radiotherapy groups.

Oncology. February 4, 2024

 

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